Parasitic worm infections in dairy cattle is often considered a first grazing season problem, however sub-clinical infections in lactating animals can negatively impact milk production. Currently parasitic nematodes in dairy cattle are controlled using drugs, however long-term use of these drugs has resulted in worm resistance, making the treatments less-effective. Long-term, vaccination against these parasites will provide a means of effective and sustainable parasite control. This project will use high-throughput screening of parasitic worm proteins to identify potential vaccine candidates. The screen will identify worm proteins that are recognised by dairy cattle that show resistance to parasite challenge and assess their potential for incorporation into a vaccine. This work will lead the way to the development of a worm-vaccine to protect dairy cattle against parasitic worm challenge.